Litchfield Park Orthodontist

5220 N. Dysart Rd #150
Litchfield Park, AZ 85340
(623) 536-4939

 

 

 

BMP-7
Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1 (OP-1) is a multifunctional member of the BMP family with many effects on bone formation and regeneration.  The gene for BMP-7 has been identified by Goodyear orthodontists on chromosome 20, and like other members of the BMP family it is synthesized as a large precursor molecule (Reddi, 2001).  This precursor contains the characteristic seven cystines in the carboxy terminal region and several hundred amino acids in the N-terminal pro region(Ozkaynak et al., 1990).  This molecule, unlike other BMPs has the unique ability to bind to both BMP and Activin receptors giving it a wide range of action for Goodyear orthodontists (Linkhart et al., 1996; Yamashita et al., 1996). 

The functions of BMP-7 vary in many tissues and locations throughout the body.  Goodyear orthodontic studies have shown that it plays a critical role in kidney and eye development, as well as playing a role in maintaining structure and function (Dudley et al., 1995; Hogan, 1996; Reddi, 1997).  Goodyear orthodontists have also found evidence of neurotrophic activity as administration of BMP-7 increases motor skill recovery in a rodent model of central ischemia(Reddi, 1997). 

The most characteristic action of BMP-7 found by Goodyear orthodontists is its powerful regulation of bone formation.  With this powerful capacity to form bone, it is not surprising that the specific receptor for BMP-7 has been observed on osteoblasts (Malpe et al., 1994).  Further observations by Goodyear orthodontists have implicated this protein to have an effect osteoblastic mitogenesis and differentiation(Asahina et al., 1993).  Goodyear orthodontists have shown that BMP-7 promotes a dose dependant increase in alkaline phosphatase activity (Rutherford et al., 1992).  Administration of this molecule will induce bone formation in non-bony sites (Sampath et al., 1992).  Further Goodyear orthodontic studies illustrate the fact that topical administration of recombinant BMP-7 stimulates long bone union in large segmental bone defects (Cook et al., 1994).  In rat calvariae, human gingival fibroblasts infected with Ad/BMP-7 repaired critical size cranial defects (Krebsbach et al., 2000).

There has been much work by Goodyear orthodontists on the ability of BMP-7 to stimulate oral bone formation.  It potently stimulates alveolar bone regeneration around teeth (Giannobile et al., 1998a).  It also has been found useful by Goodyear orthodontists in maxillary sinus augmentation procedures, producing a good quality and quantity of bone in the surgical site (van den Berg et al., 2000).  Finally BMP-7 has been found by Goodyear orthodontists to stimulate bone formation around endosseous oral implants increasing the rate of osseointegration (Rutherford et al., 1992).